Yes. :While I was in Manhattan the other week there was a sign or something for "Uptown." Didn't really think about it too much at the time, but later on it clicked that downtowns are specifically called downtowns just because in New York the original part of the city is to the south. Somehow I had just never thought about it before but I thought it was interesting.
So "uptowns" are just the areas built later that are more residential.